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Palvella Therapeutics (PVLA) Submits Initial Module of NDA For QTORIN

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Palvella Therapeutics (PVLA) Submits Initial Module of NDA For QTORIN


Palvella Therapeutics Inc. (NASDAQ:PVLA) is one of the 10 affordable biotech stocks to buy right now.

On June 29, Palvella Therapeutics Inc. (NASDAQ:PVLA) disclosed that it filed the initial module of its New Drug Application with the FDA for approval of QTORIN 3.9% rapamycin anhydrous gel. QTORIN is used to treat microcystic lymphatic malformations.

VILevi/Shutterstock.com

The company plans to file the remaining modules and conclude the NDA application process during the latter half of 2026. The company highlighted that QTORIN rapamycin has attained FDA designations for Orphan Drug, Fast Track designations, and Breakthrough Therapy. The company is also speeding up U.S. launch preparation for a possible independent commercial launch in the early half of 2027, subject to approval.

Earlier on June 22, the company revealed that the FDA had provided a rolling review for QTORIN rapamycin’s New Drug Application. Palvella Founder and CEO, Wes Kaupinen, highlighted that the company plans to use the Breakthrough Therapy, the benefits of rolling review, and Fast Track designations to facilitate an efficient route toward achieving FDA approval. He further stated:

“Following the positive Phase 3 SELVA results, our focus is clear: move with urgency to advance QTORIN rapamycin as the potential first FDA-approved therapy for patients and families affected by microcystic LMs, a serious, lifelong rare disease with no approved treatment options.”

Palvella Therapeutics Inc. (NASDAQ:PVLA) is engaged in the development and marketing of innovative medical technologies and treatments for people suffering from severe and uncommon genetic skin diseases. QTORIN rapamycin, which is the company’s leading product, is currently undergoing Phase 3 trials for microcystic lymphatic malformations and Phase 2 trials for cutaneous venous malformations.

While we acknowledge the potential of PVLA as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

READ NEXT: 33 Stocks That Should Double in 3 Years and 15 Stocks That Will Make You Rich in 10 Years.

Disclosure: None. Follow Insider Monkey on Google News.



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Humanity Protocol – H falls 15% as $36M hack returns to focus

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Humanity Protocol - H falls 15% as $36M hack returns to focus


Terence Kwok’s post-mortem interview regarding the $36 million North Korean hack triggered heavy market activity as Humanity Protocol faced renewed selling pressure. 

The interview shifted trader sentiment and pushed participants to reassess the project’s near-term outlook. 

As a result, Humanity Protocol [H] declined 14.98% over the past 24 hours to trade at $0.05697 at the time of writing. 

Trading activity accelerated instead of fading, with daily volume climbing 95.51% to $10.63 million. 

This sharp increase showed traders actively repositioned rather than abandoning the market. 

Meanwhile, the token’s market capitalization dropped to $176.54 million, reflecting a weaker valuation despite elevated participation. 

Even so, the unlocked market capitalization remained slightly higher at $176.73 million, indicating most of the circulating supply had already entered the market before the latest volatility emerged.

Why are Binance traders still leaning bullish?

Retail price action weakened considerably, yet Binance’s top traders retained a strong bullish bias throughout the sell-off. 

Long accounts represented 69.26% of positions, while short accounts accounted for only 30.74%. 

The distribution left the Long/Short Ratio at 2.25, showing experienced traders largely expected downside pressure to stabilize instead of accelerating. 

Such positioning suggested participants viewed the decline as a reaction to news rather than a complete breakdown in market structure.

However, that optimism also increased risk because excessive long exposure often creates vulnerability if support fails. 

Should sellers regain control, those leveraged long positions could add fresh volatility through forced liquidations instead of providing immediate buying support.

Can Humanity defend its long-term support?

Humanity remained pinned near the lower boundary of a long-term support zone around $0.0568 after giving back nearly all gains recorded during June’s rally. 

Buyers repeatedly defended this area over recent sessions, preventing another sharp breakdown despite persistent selling pressure. 

Meanwhile, the MACD presented an improving technical picture. 

The MACD line crossed above the signal line while the histogram turned positive, suggesting bearish pressure had eased after weeks of sustained weakness. 

However, price had not confirmed a bullish reversal because candles continued trading inside the established support range. 

If buyers maintain control above $0.0568, H could attempt a recovery toward the resistance zone near $0.080. 

However, losing that support would expose the token to another wave of selling and invalidate the improving MACD signal.

Humanity price actionHumanity price action
Source: TradingView

Where could liquidations drive the next move?

Liquidation Heatmap highlighted two important areas where volatility could intensify if price left its current range. 

The largest nearby liquidity cluster sat around $0.061, where concentrated short liquidations could accelerate a recovery if buyers reclaimed that level. 

Another significant cluster appeared around $0.055, reflecting a zone where long liquidations could emerge if support failed. 

Those stacked liquidity pockets suggested leveraged traders had concentrated positions on both sides of the market. 

As a result, any decisive move beyond either level could trigger cascading liquidations that amplify price swings. 

The stronger cluster above current price slightly favored an upward squeeze, although that scenario would still require buyers to reclaim resistance before momentum shifted convincingly.

Source: CoinGlass

Conclusively, Humanity Protocol remained under pressure after Terence Kwok’s interview reignited concerns surrounding the earlier security breach. 

However, top traders continued favoring long positions while MACD improved near a major support zone. 

If buyers defend $0.0568, H could challenge higher liquidity near $0.061. Otherwise, a break below support would likely trigger another round of liquidations and extend the recent decline.


Final Summary 

  • H dropped nearly 15% as trading volume surged following renewed hack-related market attention.
  • Bullish trader positioning remained strong while H continued testing a major long-term support level.

 



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R&A Announces Record Purse For The 2026 Open Championship

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R&A Announces Record Purse For The 2026 Open Championship


Play has begun at the 154th Open Championship, being played at Royal Birkdale Golf Club in Southport, England. This year the best golfers in the world will be playing for a record purse in the oldest championship in golf.

The Royal & Ancient Golf Club of St. Andrews (R&A), that is the governing body that oversees the Open Championship, announced earlier this week that the purse has been raised this year. The $500,000 increase from 2025 makes this year’s championship a record for player payouts. The total purse will be $17.75 million, with the winner receiving $3.2 million.

Although a record purse for the Open Championship, it still remains the lowest purse of professional golf’s major championships.

Mark Darbon, chief executive of the R&A discussed the purse increase on Wednesday at a press conference. He talked about his concerns about the rising purses in golf, as well as other issues he sees in the game.

Darbon stated, “We look at prize money as part of a broader package that we offer here at The Open Championship. We’ve also increased and continued to increase our investment into the player experience, and we’re very proud of the fact that we consistently get told by the players that the experience—the facilities, the services, the support—that we offer during Open Championship week sets the benchmark for the rest of golf. We’re intent on ensuring that that continues to remain the case.

“So prize money is but one component of that comparison. At the same time, we’re trying to find a model that gets the balance right. We have a relatively unique model at the R&A. We invest the proceeds that we generate from this Open Championship back into the sport. That’s really important for us, and we think we’re finding the right balance.”

As the last major of the season is here, golf’s governing bodies are grappling with the question of what purses may look like going forward with the possibility of LIV Golf being gone after this season. Even if LIV survives in a different form, the Saudi money will be gone, with it the large player payouts and purses that have dramatically changed the amount of money players receive. Time will tell where the money in professional golf goes from here.

2026 Open Championship Payout By Position Of Finish

Below is the amount each player will win based on their position of finish in the 2026 Open Championship at Royal Birkdale Golf Club.

1 $3,200,000
2 $1,842,000
3 $1,181,000
4 $917,000
5 $738,000
6 $639,700
7 $549,700
8 $463,250
9 $406,200
10 $367,000
11 $334,200
12 $296,000
13 $278,500
14 $260,700
15 $241,900
16 $222,700
17 $212,000
18 $202,000
19 $193,600
20 $184,500
21 $175,900
22 $167,100
23 $158,100
24 $149,300
25 $144,250
26 $138,000
27 $133,000
28 $128,400
29 $122,800
30 $116,500
31 $112,700
32 $106,900
33 $103,100
34 $100,200
35 $96,700
36 $92,900
37 $88,500
38 $84,100
39 $81,000
40 $78,400
41 $75,200
42 $71,500
43 $68,300
44 $64,400
45 $60,700
46 $57,600
47 $55,300
48 $53,100
49 $50,700
50 $49,400
51 $48,350
52 $47,500
53 $46,800
54 $46,100
55 $45,300
56 $44,700
57 $44,250
58 $43,950
59 $43,625
60 $43,325
61 $43,100
62 $42,900
63 $42,700
64 $42,500
65 $42,150
66 $41,825
67 $41,500
68 $41,200
69 $40,900
70 $40,700

Mike is a founding member of Break80 Golf and a contributing golf and sports writer for Forbes with PGA Tour and LIV Golf media credentials. Mike can be reached at break80podcast@gmail.com for inquiries or story leads.



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Visa backs Open USD with new stablecoin platform as Circle (CRCL) faces fresh competition

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Stablecoin trading volume is on track to smash records in 2026

Visa introduced a new platform aimed at making it easier for banks, fintech companies and crypto firms to build products using stablecoins, expanding its push into blockchain-based payments as competition in the sector intensifies.

The company announced on Thursday that it was launching the Visa Stablecoin Platform (VSP), an enterprise service that allows institutions to issue, store, transfer and redeem stablecoins through a single Visa-managed system. The platform launched with support for Open USD (OpenUSD), a recently introduced stablecoin from Open Standard, and includes tools for minting and redeeming the token along with wallet infrastructure for managing onchain assets.

Stablecoins are cryptocurrencies designed to maintain a fixed value, typically by being pegged to the U.S. dollar. Unlike bitcoin or ether (ETH), they are widely used for payments, cross-border transfers and settlement because they combine blockchain’s speed with a relatively stable price.

Visa said the platform provides Wallet-as-a-Service infrastructure, blockchain connectivity and security features such as dual-approval workflows, audit logs and transfer allow lists. The platform is also integrated with Visa’s existing payment network, allowing financial institutions to incorporate stablecoins into treasury management, settlement and payment products without replacing their existing systems.



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Limited-time offer: Earn up to $500 in travel credits with a Capital One business credit card

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Limited-time offer: Earn up to $500 in travel credits with a Capital One business credit card


New Capital One Spark Cash Plus and Capital One Spark Cash cardholders can earn credits to use toward travel booked with Capital One Business Travel. With a Spark Cash Plus card, you can earn a $500 travel credit after spending $30,000 in the first three months. You’ll get a $250 travel credit with the Capital One Spark Cash after spending $10,000 in the first three months. 

Even better — you can earn these travel credits alongside the cards’ regular welcome bonuses.

$0 for the first year, then $95

Earn a $1,000 cash bonus plus for a limited time, earn a $250 Capital One Business Travel credit when you spend $10,000 within 3 months of account opening

Earn $2,000 cash back after spending $30,000 within the first 3 months, plus get an additional $2,000 cash bonus for every $500,000 spent during the first year

Read more: Best business credit cards

With this limited-time offer, you can earn a regular welcome bonus with either the Spark Cash Plus or Spark Cash, and get an additional bonus to use when you book with Capital One Business Travel.

Here’s what both cards’ combined new bonuses will look like with the offer:

  • Capital One Spark Cash Plus: Earn $2,000 cash back and a $500 Capital One Business Travel credit when you spend $30,000 within the first three months of account opening. You can also earn an additional $2,000 cash bonus for every $500,000 you spend within the first year.

  • Capital One Spark Cash: Earn $1,000 cash back and a $250 Capital One Business Travel credit when you spend $10,000 within the first three months of account opening.

You can redeem the standard cash-back bonus, along with cash-back rewards you earn, for a statement credit or check. The travel credit can be redeemed for flights, hotels, and more for your next business trip via Capital One Business Travel.    

  • Annual fee

    $150

  • Welcome offer

    Earn $2,000 cash back after spending $30,000 within the first 3 months, plus get an additional $2,000 cash bonus for every $500,000 spent during the first year

  • Purchase APR

    25.74% variable

  • Rewards rate

    • 5% unlimited cash back on hotels and rental cars booked through Capital One Business Travel
    • 2% unlimited cash back on all other purchases (no limits or category restrictions)
  • Benefits

    • Get your $150 annual fee refunded every year after spending at least $150,000
    • Your spending limit is flexible and adjusts based on factors such as your purchase, payment, and credit history
    • You’ll never be charged interest since your balance is due in full every month

Read our full Capital One Spark Cash Plus review

  • Annual fee

    $0 for the first year, then $95

  • Welcome offer

    Earn a $1,000 cash bonus plus for a limited time, earn a $250 Capital One Business Travel credit when you spend $10,000 within 3 months of account opening

  • Purchase APR

    24.49% variable

  • Rewards rate

    • 5% unlimited cash back on hotels, vacation rentals, and rental cars booked through Capital One’s travel booking site
    • 2% unlimited cash back on all other purchases
  • Benefits

    • Simplify your recordkeeping by downloading your purchase records in multiple formats such as Quicken or QuickBooks
    • Enjoy international travel without additional fees on purchases made abroad

Read more: Best Capital One credit cards

Capital One’s Spark Cash Plus and Spark Cash cards are cash-back business credit cards, but they also offer solid savings for business travelers. 

Both cards earn 2% cash back on every purchase, as well as 5% cash back on hotels and rental cars booked through Capital One Business Travel. Booking through the Capital One portal can help you track travel expenses throughout your company and score discounted corporate rates for select hotels and airlines. 

Still, the Spark Cash Plus and Spark Cash cards are best for their simple 2% cash-back rewards on every business expense — not just travel.

The Capital One Spark Cash Plus is better for business owners with large annual budgets. The more you spend with this card, the more you can get rewarded. In addition to the high spending required for the first-year bonuses, you’ll get the $150 fee refunded each year when you spend at least $150,000. It also has no preset spending limit, so you’ll have more flexibility when you need to make large purchases.

With the Capital One Spark Cash card, you can earn the same 2% cash back on every purchase. But this card has a lower $95 annual fee, which is waived for the first year. If your business budget isn’t high enough to take full advantage of the Spark Cash Plus, this is another great option for earning rewards on every purchase.

For example, let’s say you spend about $100,000 using your business credit card each year: $10,000 on hotels or rental cars that you can book through Capital One Business Travel, and the rest on various expenses. With either card, that equals about $2,300 in total cash-back rewards each year. 

However, these expenses aren’t enough to get the Spark Cash Plus card’s $150 annual fee refunded, and you may have difficulty qualifying for the welcome bonus. But with the Spark Cash card, you can easily meet the spending required for the welcome bonus with this budget, and you’ll pay no annual fee for the first year (with a lower $95 fee after that). 

If your annual business spending is regularly upwards of $150,000 and you plan to spend at least $30,000 within the next three months, you may get more value from the Spark Cash Plus. Otherwise, you’ll likely find more valuable savings on business expenses with the Spark Cash card. 


Editorial Disclosure: The information in this article has not been reviewed or approved by any advertiser. All opinions belong solely to Yahoo Finance and are not those of any other entity. The details on financial products, including card rates and fees, are accurate as of the publish date. All products or services are presented without warranty. Check the bank’s website for the most current information. This site doesn’t include all currently available offers. Credit score alone does not guarantee or imply approval for any financial product.



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Crypto.com lands $400 million investment from Citadel Securities at $20 billion valuation

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Crypto.com lands $400 million investment from Citadel Securities at $20 billion valuation

Crypto.com secured a $400 million strategic investment from market maker Citadel Securities in a deal that values the crypto exchange at $20 billion, marking the firm’s first institutional funding round since it was founded a decade ago, the company said in a press release Thursday.

The funding comes as digital assets draw greater participation from traditional financial institutions and as tokenized assets emerge as a growing area of focus for the industry.

The Singapore-based exchange said the capital will accelerate its expansion into tokenized securities, derivatives and other asset classes, as it seeks to bridge traditional and digital markets with around-the-clock trading infrastructure.

The deal reflects a broader shift as traditional finance firms ramp up investments in crypto infrastructure. Since the introduction of spot bitcoin exchange-traded funds (ETFs) in January 2024, Wall Street firms have increasingly expanded into digital asset trading, tokenization and custody, while institutional investors continue to boost planned crypto allocations, according to EY research.

“The size of the opportunity in front of us is staggering, as crypto increasingly becomes the rails for finance,” Crypto.com co-founder and CEO Kris Marszalek said in the release.



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Polygon Labs announces second round of 2026 layoffs as it targets profitability in 2027

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Polygon Labs announces second round of 2026 layoffs as it targets profitability in 2027


On Thursday, July 16, Polygon Labs [POL] CEO Marc Boiron announced the second round of layoffs for 2026.

Polygon was in the final stages of completing the Coinme acquisition, and this move will help transition the blockchain company towards a “blockchain-enabled payments company”, the CEO wrote in a post on X.

Marc Polygon Labs
Source: Marc Boiron on X

Hence, the “difficult, but necessary” decision to let people go was made. This was the company’s fourth wave of reductions dating back to February 2023.

Coinme, the crypto exchange, and Sequence, the wallet infrastructure firm, were acquired for $250 million in January 2026. Layoffs of 60 staff members back then had been because the company was pivoting to a payment focused blockchain. They were part of restructuring after the acquisitions, a spokesperson had said.

The vision for the Polygon Open Stack is to enable seamless money transfers onchain, explaining the need for these acquisitions and their integrations.

Specific figures were not shared for Thursday’s layoffs.

The path ahead for POL

It was reported that a Polygon representative observed that the Polygon Labs and Polygon Foundation were legally and structurally distinct entities. The acquisitions and commercial vision of the former has been laid out.

Meanwhile, the Foundation is tasked with network upgrades, treasury, and ecosystem. POL, the network’s native token, was down nearly 94% from its all-time highs. Its holders have no equity and no claim in Polygon Labs’ future profits.

As such, the token’s bearish price action could be set to continue in the long-run, unless network utility picks up, creating more demand and forcing more token burns through the deflationary mechanic.

POL 12-hour ChartPOL 12-hour Chart
Source: POL/USDT on TradingView

The A/D indicator signaled buying pressure in July, and the DMI showed an uptrend in progress. Yet, the technical indicators did not capture the longer-term downtrend.

POL was down 56% since making a high of $0.186 in January earlier this year. The gains in July were not enough to shift the trend bullishly. A price move beyond $0.095 is needed.

Beyond the price action of the past six weeks, increased network usage and organic POL demand is needed to drive its recovery.


Final Summary

  • Polygon Labs CEO Marc Boiron announced the second round of layoffs for 2026, as the firm moved to finalize the Coinme acquisition.
  • The Polygon Open Money Stack vision envisioned as a seamless, global, blockchain-based payments platform.

 



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